nocturnal leg cramps การใช้

• The duration of nocturnal leg cramps is variable, with cramps lasting anywhere from a few seconds to several minutes.
• Nocturnal leg cramps ( almost exclusively calf cramps ) are considered " normal " during the late stages of pregnancy.
• Quinine is no longer recommended for treatment of nocturnal leg cramps due to potential fatal hypersensitivity reactions and thrombocytopenia . hemolytic uremic syndrome can also occur at higher dosages.
• In the past, quinine was frequently prescribed in the US as an off-label treatment for nocturnal leg cramps, but this has become less prevalent due to a Food and Drug Administration statement warning against the practice.
• Quinine, a toxic plant alkaloid, is, in addition to its anti-malarial properties, an effective muscle relaxant, as the modern use for nocturnal leg cramps suggests ( corroborating its use for shivering by the Peruvian Indians ).